We offer wide spectrum of tests focused on converting chemical processes from laboratory to industrial scale. The goal is to design a robust technological process and prepare a sufficient volume of product for testing in real application conditions so as to speed up the process of transferring new technologies into industrial realisation. We have experience with the individual stages of the technology transfer and offers partnership in the form of services that will enable the entire process to be brought to a successful end.
As part of the upscaling process, we perform the following activities:
Optomization of laboratory synthesis to meet the requirements of industrial production.
Verification of complete analytical control of the entire chemical process, including determination of the effect of key pollutants on product quality and yield.
Design and verification of processes for product purification.
Finalization of the application form of the product, mainly as dispersion, emulsion, solution or in fine powder form.
All services offred are available in laboratory scale, glass pilot scale (15 to 100 L apparatus) and pilot scale (600 L apparatus suitable for working in acidic and parallelly basic environments).
We offer services in the area:
Synthesis of organic compounds and special colorants using common synthetic procedures in the temperature range from -15 to +180 °C and pressures from 10 mbar to 3 bar.
Verification of the proposed synthetic procedures in apparatus from 1 až do 600 l, determining the effect of upscaling on the proposed procedures and debugging the technology so that the given process can be repeated reproducibly.
Synthesis of a polyurethane solution with chemically bound functional groups for spinning processes with a special focus on the production of nanofibers with antimicrobial properties, with non-flammable and medical applications.
Design of purification methods for organic compounds based on extraction, crystallization, column and flash chromatography, lyophilization, vacuum distallation and sublimation.
Production of products in a volume of 100 g to 100 kg as a follow-up to R&D activities with the aim of launching a new product on the market.
Preparation of stable micro- and nano-dispersions using the pearl grinding technique.
Preparation of emulsions or dispersions of gel-like particles using the mixing technique (up to 10,000 rpm) or a high-pressure homogenizer for pressures up to 300 bar.
Development of analytical methods in the field of HPLC, GC, UV/VIS, NIR and fluorescence spectrometry or a wide range of titration methods. characterization of dispersions by the DLS technique, optical microscopy and measurement of the morphology of thin films by a contact profilometer.
Measurement of the electrical conductivity of materials by the two- and four-point method and the method according to Van der Pauw.
Elektrochemical measurements, characterization of flow batteries, testing of electrochromic systems.
Determination of total and specific migration from thin films or materials using standard simulants.
Technology transfer :
In our understanding, the transfer of chemical product production technology from laboratory to industrial scale, completed by successful commercialization and proper regular production, is a long-term process requiring the following time-consuming steps:
Debugging the chemical synthesis process that all hidden defects that negatively affect the quality and production yield are removed. At each stage of upscaling, new facts affecting the chemical process may appear, which must be correctly set and debugged in repeated batches.
Setting up a system of control analyses during the production process and for the control of input raw materials and final product.
Optimizing solvent recycling to minimize the cost and carbon footprint associated with production while properly setting up recycled solvent quality control.
Cleaning of equipment enabling the smooth production of other chemical products.
The launch of a new product on the market entails a request from the end users to test materials in smaller batches, for which semi-operational equipment is suitable. Repetition of production in smaller volumes will make it possible to better verify the correct setting of the production proces.
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